Daniel C. Marcus
Emeritus Professor
DSc, Electrical/Biomedical Engineering, Washington University, 1976
Research Interests
We have studied the cellular mechanisms used by inner ear epithelia to create and maintain the unusual ionic composition of "endolymph" in the luminal compartment. Normal endolymph composition is essential for healthy hearing and balance. More information on laboratory techniques, publications and projects is available within these web pages.
Alumni | Techniques | Projects
Seminars
Selected publications 2002-2018
Kudo T., Wangemann P., and Marcus D.C.. (2018) Claudin expression during early postnatal development of the murine cochlea. BMC Physiology. Jan 25; 18(1):1. doi: 10.1186/s12899-018-0035-1.
Miyazaki, H., Wangemann, P. and Marcus, D.C. (2016) The gastric H,K-ATPase in stria vascularis contributes to pH regulation of cochlear endolymph but not to K secretion. BMC Physiology Aug. 11; 17(1):1. doi: 10.1186/s12899-016-0024-1
Kim, K.X., Sanneman, J.D., Kim, H.M., Harbidge, D.G., Xu, J., Soleimani, M., Wangemann, P., Marcus, D.C. (2014) Slc26a7 chloride channel activity and localization in mouse Reissner’s membrane epithelium. PLoS One 9(5): e97191.
Li, X., Sanneman, J. D., Harbidge, D. G., Zhou, F., Ito, T., Nelson, R.D., Picard, N., Chambrey, R., Eladari, D., Miesner, T., Griffith, A.J., Marcus, D.C., Wangemann, P. (2013) SLC26A4 targeted to the endolymphatic sac rescues hearing and balance in Slc26a4 mutant mice. PLoS Genet 9(7): e1003641.
Pondugula, S.R., Kampalli, S.B., Wu, T., De Lisle, R.C., Raveendran, N.N., Harbidge, D.G. and Marcus, D.C. (2013) cAMP-stimulated Cl- secretion is increased by glucocorticoids and inhibited by bumetanide in semicircular canal duct epithelium. BMC Physiology, 13, 6.
Li, X., Zhou, F., Marcus, D.C., Wangemann, P. (2013) Endolymphatic Na+ and K+ concentrations during cochlear growth and enlargement in mice lacking Slc26a4/pendrin. PLoSOne 8(5), e65977.
Li, X., Sanneman, J. D., Harbidge, D. G., Zhou, F., Ito, T., Nelson, R.D., Picard, N., Chambrey, R., Eladari, D., Miesner, T., Griffith, A.J., Marcus, D.C., Wangemann, P. (2013) SLC26A4 targeted to the endolymphatic sac rescues hearing and balance in Slc26a4 mutant mice. PLoS Genet 9(7): e1003641.
Yamazaki, M., Wu, T., Pondugula, S.R., Harbidge, D.G., and Marcus, D.C. (2011) Sodium selectivity of semicircular canal duct epithelial cells. BMC Research Notes 4, 355.
Yamazaki, M., Kim, K.X. and Marcus, D.C. (2011) Sodium selectivity of Reissner's membrane epithelial cells. BMC Physiology 11, 4.
Kim, S.H. and Marcus, D.C. (2011) Regulation of sodium transport in the inner ear. Hearing Res. 280, 21-29.
Kim, K.X. and Marcus, D.C. (2010) Inward-rectifier chloride currents in Reissner's membrane epithelial cells. Biochem. Biophys. Res. Comm. 394, 434-438.
Yamauchi, D., Nakaya, K., Raveendran, N.N., Harbidge, D.G., Singh, R., Wangemann, P., Marcus, D.C. (2010) Expression of epithelial calcium transport system in rat cochlea and vestibular labyrinth. BMC Physiology 10, 1.
Kim, S.H., Kim, K.X., Raveendran, N.N., Pondugula, S.R., Wu, T. and Marcus, D.C. (2009) Regulation of ENaC-mediated sodium transport by glucocorticoids in Reissner's membrane epithelium. Am. J. Physiol.: Cell Physiology 296, C544 - C557.
Lee, J.H. and Marcus, D.C. (2008) Purinergic signaling in the inner ear. Hearing Res. 235, 1-7.
Nakaya, K., Harbidge, D.G., Wangemann, P. Schultz, B.D. and Marcus, D.C. (2007) Lack of pendrin HCO3- transport elevates vestibular endolymphatic [Ca2+] by inhibition of acid-sensitive TRPV5 and TRPV6 channels. Am. J. Physiol.: Renal Physiology 292, F1314–F1321.
Pondugula, S.R., Raveendran, N.N., Ergonul, Z., Deng, Y.P., Chen, J., Sanneman, J.D., Palmer, L.P., Marcus, D.C. (2006) Glucocorticoid regulation of genes involved in Na+ transport by semicircular canal duct epithelium. Physiological Genomics 24, 114-123.
Yamauchi, D., Raveendran, N.N., Pondugula, S.R., Kampalli, S.B., Sanneman, J.D., Harbidge, D.G., Marcus, D.C. (2005) Vitamin D upregulates expression of ECaC1 mRNA in semicircular canal. Biochem. Biophys. Res. Comm. 331, 1353-1357.
Pondugula, S.R., Sanneman, J.D., Wangemann P., Milhaud, P.G. and Marcus, D.C. (2004) Glucocorticoids stimulate cation absorption by semicircular canal duct epithelium via epithelial sodium channel. Am. J. Physiol.:Renal Physiol. 286, F1127-F113.
Lee, J.H. and Marcus, D.C. (2003) Endolymph sodium homeostasis by Reissner's membrane. Neurosci. 119, 3-8.
Milhaud, P.G., Pondugula, S.R., Lee, J.H., Herzog, M., Lehouelleur, J., Wangemann, P., Sans, A. and Marcus, D.C. (2002) Chloride secretion by semicircular canal duct epithelium is stimulated via beta2-adrenergic receptors. Am. J. Physiol. 283, C1752-C1760.
Marcus, D.C., Wu, T., Wangemann, P. and Kofuji, P. (2002) KCNJ10 (Kir4.1) potassium channel knockout abolishes endocochlear potential. Am. J. Physiol. 282, C403-C407.